Is a bacterial RNA

Transfer-messenger RNA is a bacterial RNA molecule with dual tRNA-like and messenger RNA-like properties. The tmRNA forms a ribonucleoprotein complex (tmRNP) together with Small Protein B (SmpB), Elongation Factor Tu (EF-Tu), and ribosomal protein S1. In trans-translation, tmRNA and its associated proteins bind to bacterial ribosomes which have stalled in the middle of protein biosynthesis, for example when reaching the end of a messenger RNA which has lost its stop codon. The tmRNA is remarkably versatile: it recycles the stalled ribosome, adds a proteolysis-inducing tag to the unfinished polypeptide, and facilitates the degradation of the aberrant messenger RNA. In the majority of bacteria these functions are carried out by standard one-piece tmRNAs. In other bacterial species, a permuted ssrA gene produces a two-piece tmRNA in which two separate RNA chains are joined by base-pairing.

The Shelbyville Historic District is a historic district encompassing the core of Shelbyville, Illinois. The district includes 398 buildings, 293 of which are contributing buildings. The section of Shelbyville laid out at the city's founding in 1827 forms the center of the district. Shelbyville's public square, which includes the 1880 Shelby County Courthouse and a veterans' memorial, is the central feature of this part of the historic district. The original section of Shelbyville also includes significant commercial and government buildings. The district also includes Shelbyville's oldest residential areas, which developed out from the 1827 core. The Italianate style is the most prominent architectural style in the district, both in homes and commercial buildings; other common architectural styles include Greek Revival, Gothic Revival, Second Empire, and Queen Anne.